| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM39 (350-450) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM39 |
| Gene ID: |
56658 |
| Uniprot ID: |
TRI39_HUMAN |
| Immunogen Region: |
350-450 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human TRIM39 (NP_067076.2). |
| Immunogen Sequence: |
LVLSEDRKSVKFVETRLRDL PDTPRRFTFYPCVLATEGFT SGRHYWEVEVGDKTHWAVGV CRDSVSRKGELTPLPETGYW RVRLWNGDKYAATTTPFTPL H |
| Tissue Specificity | Ubiquitous.highly expressed in brain, heart, kidney, liver, skeletal muscle, spleen and testis. |
| Post Translational Modifications | Autoubiquitinated. |
| Function | Isoform 1: E3 ubiquitin-protein ligase. May facilitate apoptosis by inhibiting APC/C-Cdh1-mediated poly-ubiquitination and subsequent proteasome-mediated degradation of the pro-apoptotic protein MOAP1. Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Isoform 2: Regulates the G1/S transition of the cell cycle and DNA damage-induced G2 arrest by stabilizing CDKN1A/p21. Positively regulates CDKN1A/p21 stability by competing with DTL for CDKN1A/p21 binding, therefore disrupting DCX(DTL) E3 ubiquitin ligase complex-mediated CDKN1A/p21 ubiquitination and degradation. Negatively regulates the canonical NF-kappa-B signaling pathway via stabilization of CACTIN in an ubiquitination-independent manner. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim39Ring Finger Protein 23Ring-Type E3 Ubiquitin Transferase Trim39Testis-Abundant Finger ProteinTripartite Motif-Containing Protein 39 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Isoform 1: CytoplasmCytosolMitochondrionNucleusFound Predominantly In The CytosolPartial Shift From The Cytosol To The Mitochondria When Colocalized With Moap1Colocalizes With Cdkn1a In The NucleusIsoform 2: Nucleus |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim39 antibodyAnti-Ring Finger Protein 23 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim39 antibodyAnti-Testis-Abundant Finger Protein antibodyAnti-Tripartite Motif-Containing Protein 39 antibodyAnti-TRIM39 antibodyAnti-RNF23 antibodyAnti-TFP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
