| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TRIM38 (266-465) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TRIM38 |
| Gene ID: |
10475 |
| Uniprot ID: |
TRI38_HUMAN |
| Immunogen Region: |
266-465 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 266-465 of human TRIM38 (NP_006346.1). |
| Immunogen Sequence: |
VSLELHTMCNVSKLYFDVKK MLRSHQVSVTLDPDTAHHEL ILSEDRRQVTRGYTQENQDT SSRRFTAFPCVLGCEGFTSG RRYFEVDVGEGTGWDLGVCM ENVQRGTGMKQEPQSGFWTL RLCKKKGYVALTSPPTSLHL HEQPLLVGIFLDYEAGVVSF YNGNTGCHIFTFPKASFSDT LRPYFQVYQYSPLFLPPPGD |
| Tissue Specificity | Ubiquitous. |
| Function | E3 ubiquitin-protein and E3 SUMO-protein ligase that acts as a regulator of innate immunity. Acts as a negative regulator of type I interferon IFN-beta production by catalyzing 'Lys-48'-linked polyubiquitination of AZI2/NAP1, leading to its degradation. Mediates 'Lys-48'-linked polyubiquitination and proteasomal degradation of the critical TLR adapter TICAM1, inhibiting TLR3-mediated type I interferon signaling. Acts as positive regulator of the cGAS-STING pathway by acting as a E3 SUMO-protein ligase: mediates sumoylation of CGAS and STING, preventing their degradation and thereby activating the innate immune response to DNA virus. Also acts as a negative regulator of NF-kappa-B signaling independently of its E3 protein ligase activity by promoting lysosome-dependent degradation of TAB2 and TAB3 adapters. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim38Ring Finger Protein 15Tripartite Motif-Containing Protein 38Zinc Finger Protein Roret |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim38 antibodyAnti-Ring Finger Protein 15 antibodyAnti-Tripartite Motif-Containing Protein 38 antibodyAnti-Zinc Finger Protein Roret antibodyAnti-TRIM38 antibodyAnti-RNF15 antibodyAnti-RORET antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
