Anti-TRIM37 antibody (C-Term) (STJ70249)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
General Information
| Short Description | Goat polyclonal antibody anti-TRIM37 (C-Term) is suitable for use in ELISA, Immunofluorescence and Flow Cytometry research applications. |
| Applications | Pep-ELISA/IF/FC |
| Host | Goat |
| Reactivity | Human/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:64000.IF: Strong expression of the protein seen in the cytoplasm and nuclei of HeLa cells. Recommended concentration: 10µg/ml. FC:Flow cytometric analysis of HeLa cells. Recommended concentrat |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM37 |
| Gene ID | 4591 |
| Uniprot ID | TRI37_HUMAN |
| Accession Number | NP_056109.1;Isotype=IgG" |
| Immunogen Region | C-Term |
| Immunogen Sequence | EDLSFNTDENSGR |
| Specificity | Expercted to recognise all reported isoforms a to i |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated. |
| Function | E3 ubiquitin-protein ligase required to prevent centriole reduplication. Probably acts by ubiquitinating positive regulators of centriole reduplication. Mediates monoubiquitination of 'Lys-119' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes. Also acts as a positive regulator of peroxisome import by mediating monoubiquitination of PEX5 at 'Lys-472': monoubiquitination promotes PEX5 stabilitation by preventing its polyubiquitination and degradation by the proteasome. Has anti-HIV activity. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim37Mulibrey Nanism ProteinRing-Type E3 Ubiquitin Transferase Trim37Tripartite Motif-Containing Protein 37 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | ChromosomeCytoplasmPerinuclear RegionPeroxisome MembranePeripheral Membrane ProteinFound In Vesicles Of The PeroxisomeAggregates As AggresomesA Perinuclear Region Where Certain Misfolded Or Aggregated Proteins Are Sequestered For Proteasomal Degradation |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim37 antibodyAnti-Mulibrey Nanism Protein antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim37 antibodyAnti-Tripartite Motif-Containing Protein 37 antibodyAnti-TRIM37 antibodyAnti-KIAA0898 antibodyAnti-MUL antibodyAnti-POB1 antibody |
Information sourced from Uniprot.org