Anti-TRIM34 antibody (STJA0004746)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide of human TRIM34
General Information
| Short Description | Rabbit polyclonal anti-Tripartite Motif-Containing Protein 34 for use in WB, IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.4 mg/mL |
| Purification | Affinity purification |
| Dilution Range | WB 1:200-1:1000, IHC 1:25-1:100 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM34 |
| Gene ID | 53840 |
| Uniprot ID | TRI34_HUMAN |
| Immunogen | Synthetic peptide of human TRIM34 |
Additional Info
| Tissue Specificity | Isoform 1: Is the most abundant form. It is highly expressed in the placenta, spleen, colon and peripheral blood leukocytes. |
| Function | Functions as antiviral protein and contributes to the defense against retroviral infections. Acts as a capsid-specific restriction factor with the help of TRIM5 and prevents infection from non-host-adapted retroviruses. During influenza A virus infection, promotes programmed cell death by targeting ZBP1 for 'Lys-63'-linked polyubiquitination. In turn, promotes ZBP1 recruitment of RIPK3 to mediate virus-induced programmed necrosis. Negatively regulates the function of mitochondria by enhancing mitochondrial depolarization leading to cytochrome c release and mitochondria-dependent apoptosis. Also promotes the formation of multinucleated giant cells by means of cell fusion and phagocytosis in epithelial cells. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim34Interferon-Responsive Finger Protein 1Ring Finger Protein 21 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmMitochondrionLocalizes In Cytoplasmic Bodies Together With Trim5 And Incoming Hiv-1 Capsids During Infection |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim34 antibodyAnti-Interferon-Responsive Finger Protein 1 antibodyAnti-Ring Finger Protein 21 antibodyAnti-TRIM34 antibodyAnti-IFP1 antibodyAnti-RNF21 antibody |
Information sourced from Uniprot.org