Anti-TRIM31 antibody (STJ191803)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-E3 ubiquitin-protein ligase TRIM31 for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM31 |
| Gene ID | 11074 |
| Uniprot ID | TRI31_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TRI31 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Auto-ubiquitinated (in vitro). |
| Function | E3 ubiquitin-protein ligase that acts as a regulator of antiviral immune response and inflammation by mediating ubiquitination of substrates. Acts as a regulator of innate immune defense against viruses by mediating 'Lys-63'-linked ubiquitination of MAVS, promoting MAVS polymerization and formation of three-stranded helical filaments on mitochondria. Acts as a negative regulator of the NLRP3 inflammasome by catalyzing 'Lys-48'-linked ubiquitination of NLRP3, leading to its degradation. Regulator of Src-induced anchorage independent cell growth. |
| Protein Name | E3 Ubiquitin-Protein Ligase Trim31Tripartite Motif-Containing Protein 31 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmMitochondrionPredominantly Expressed In The Cytoplasm But A Fraction Is Associated With The MitochondriaRecruited T Omitochondria After Viral Infection |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Trim31 antibodyAnti-Tripartite Motif-Containing Protein 31 antibodyAnti-TRIM31 antibodyAnti-C6orf13 antibodyAnti-RNF antibody |
Information sourced from Uniprot.org