Anti-TRIM3 antibody (1-50 aa) (STJ96101)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TRIM3 at the amino acid range 1-50
General Information
| Short Description | Rabbit polyclonal anti-Tripartite motif-containing protein 3 (1-50 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:40000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM3 |
| Gene ID | 10612 |
| Uniprot ID | TRIM3_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TRIM3 at the amino acid range 1-50 |
| Immunogen Region | 1-50 aa |
| Specificity | TRIM3 Polyclonal Antibody detects endogenous levels of TRIM3 protein. |
Additional Info
| Function | E3 ubiquitin ligase that plays essential roles in neuronal functions such as regulation of neuronal plasticity, learning, and memory. In addition to its neuronal functions, participates in other biological processes such as innate immunity or cell cycle regulation. Component of the cytoskeleton-associated recycling or transport complex in neurons, polyubiquitinates gamma-actin, thus regulating neuronal plasticity, learning, and memory. Ubiquitinates postsynaptic scaffold GKAP, a neuronal substrate involved in synaptic remodeling and thereby modulates dendritic spine morphology. Positively regulates motility of microtubule-dependent motor protein KIF21B. Induces growth arrest via its RING-dependent E3 ligase activity and ubiquinates CDKN1A. Positively regulates TLR3-mediated signaling by mediating 'Lys-63'-linked polyubiquitination of TLR3. In turn, promotes the recognition and sorting of polyubiquitinated TLR3 by the ESCRT complexes. |
| Protein Name | Tripartite Motif-Containing Protein 3Brain-Expressed Ring Finger ProteinRing Finger Protein 22Ring Finger Protein 97 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | CytoplasmEarly EndosomeGolgi ApparatusTrans-Golgi NetworkCell ProjectionDendriteMainly Located In The Golgi Apparatus And Transported To The Early Endosomes Upon Stimulation With Dsrna |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 3 antibodyAnti-Brain-Expressed Ring Finger Protein antibodyAnti-Ring Finger Protein 22 antibodyAnti-Ring Finger Protein 97 antibodyAnti-TRIM3 antibodyAnti-BERP antibodyAnti-RNF22 antibodyAnti-RNF97 antibody |
Information sourced from Uniprot.org