| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Dog/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-TRIM2 (233-247) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 80kDa band observed in Mouse Brain lysates (calculated MW of 81.4kDa according to Mouse NP_109631.1). Recommended concentration: 0.1-0.3µg/ml. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | TRIM2 |
| Gene ID: | 23321 |
| Uniprot ID: | TRIM2_HUMAN |
| Immunogen Region: | 233-247 |
| Accession Number: | NP_056086.2; NP_001123539.1 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_056086.2; NP_001123539.1). |
| Immunogen Sequence: | STFDELQKTLNVRKS |
| Function | UBE2D1-dependent E3 ubiquitin-protein ligase that mediates the ubiquitination of NEFL and of phosphorylated BCL2L11. Plays a neuroprotective function. May play a role in neuronal rapid ischemic tolerance. Plays a role in antiviral immunity and limits New World arenavirus infection independently of its ubiquitin ligase activity. |
| Protein Name | Tripartite Motif-Containing Protein 2E3 Ubiquitin-Protein Ligase Trim2Ring Finger Protein 86Ring-Type E3 Ubiquitin Transferase Trim2 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 2 antibodyAnti-E3 Ubiquitin-Protein Ligase Trim2 antibodyAnti-Ring Finger Protein 86 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Trim2 antibodyAnti-TRIM2 antibodyAnti-KIAA0517 antibodyAnti-RNF86 antibody |
Information sourced from Uniprot.org