Anti-TRIM10 antibody (STJA0004855)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human TRIM10
General Information
| Short Description | Rabbit polyclonal anti-Tripartite Motif-Containing Protein 10 for use in IHC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:25-100 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TRIM10 |
| Gene ID | 10107 |
| Uniprot ID | TRI10_HUMAN |
| Immunogen | Fusion protein of human TRIM10 |
Additional Info
| Function | E3 ligase that plays an essential role in the differentiation and survival of terminal erythroid cells. May directly bind to PTEN and promote its ubiquitination, resulting in its proteasomal degradation and activation of hypertrophic signaling. In addition, plays a role in immune response regulation by repressing the phosphorylation of STAT1 and STAT2 in the interferon/JAK/STAT signaling pathway independent of its E3 ligase activity. Mechanistically, interacts with the intracellular domain of IFNAR1 and thereby inhibits the association between TYK2 and IFNAR1. |
| Protein Name | Tripartite Motif-Containing Protein 10B30-Ring Finger ProteinRing Finger Protein 9 |
| Database Links | Reactome: R-HSA-877300 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Tripartite Motif-Containing Protein 10 antibodyAnti-B30-Ring Finger Protein antibodyAnti-Ring Finger Protein 9 antibodyAnti-TRIM10 antibodyAnti-RFB30 antibodyAnti-RNF9 antibody |
Information sourced from Uniprot.org