• Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-kidney, antibody was diluted at 1:200
  • Immunohistochemical analysis of paraffin-embedded human-liver, antibody was diluted at 1:200

Anti-TRAP1 antibody (481-530 aa) (STJ98811)

SKU:
STJ98811

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Heat shock protein 75 kDa, mitochondrial (481-530 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-200
ELISA 1:10000-20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TRAP1
Gene ID: 10131
Uniprot ID: TRAP1_HUMAN
Immunogen Region: 481-530 aa
Specificity: The antibody detects endogenous HSP 75
Immunogen: The antiserum was produced against synthesized peptide derived from the Internal region of human TRAP1 at the amino acid range 481-530
Function Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.
Protein Name Heat Shock Protein 75 Kda - Mitochondrial
Hsp 75
Tnfr-Associated Protein 1
Tumor Necrosis Factor Type 1 Receptor-Associated Protein
Trap-1
Database Links Reactome: R-HSA-611105
Cellular Localisation Mitochondrion
Mitochondrion Inner Membrane
Mitochondrion Matrix
Alternative Antibody Names Anti-Heat Shock Protein 75 Kda - Mitochondrial antibody
Anti-Hsp 75 antibody
Anti-Tnfr-Associated Protein 1 antibody
Anti-Tumor Necrosis Factor Type 1 Receptor-Associated Protein antibody
Anti-Trap-1 antibody
Anti-TRAP1 antibody
Anti-HSP75 antibody

Information sourced from Uniprot.org

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