Anti-TRAP1 antibody (481-530 aa) (STJ98811)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human TRAP1 at the amino acid range 481-530
General Information
| Short Description | Rabbit polyclonal anti-Heat shock protein 75 kDa, mitochondrial (481-530 aa) for use in IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-200ELISA 1:10000-20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRAP1 |
| Gene ID | 10131 |
| Uniprot ID | TRAP1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human TRAP1 at the amino acid range 481-530 |
| Immunogen Region | 481-530 aa |
| Specificity | The antibody detects endogenous HSP 75 |
Additional Info
| Function | Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA. |
| Protein Name | Heat Shock Protein 75 Kda - MitochondrialHsp 75Heat Shock Protein Family C Member 5Tnfr-Associated Protein 1Tumor Necrosis Factor Type 1 Receptor-Associated ProteinTrap-1 |
| Database Links | Reactome: R-HSA-611105Reactome: R-HSA-71403 |
| Cellular Localisation | MitochondrionMitochondrion Inner MembraneMitochondrion Matrix |
| Alternative Antibody Names | Anti-Heat Shock Protein 75 Kda - Mitochondrial antibodyAnti-Hsp 75 antibodyAnti-Heat Shock Protein Family C Member 5 antibodyAnti-Tnfr-Associated Protein 1 antibodyAnti-Tumor Necrosis Factor Type 1 Receptor-Associated Protein antibodyAnti-Trap-1 antibodyAnti-TRAP1 antibodyAnti-HSP75 antibodyAnti-HSPC5 antibody |
Information sourced from Uniprot.org