Anti-Transcription Factor 7 Like 1 antibody [R05-2J4] (STJA0035867)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TCF3
General Information
| Short Description | Rabbit monoclonal anti-Transcription Factor 7 Like 1 for use in WB and FC in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/FC |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R05-2J4 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000FC 1:50-1:100 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TCF7L1 |
| Gene ID | 83439 |
| Uniprot ID | TF7L1_HUMAN |
| Immunogen | A synthesized peptide derived from human TCF3 |
Additional Info
| Tissue Specificity | Detected in hair follicles and skin keratinocytes, and at lower levels in stomach epithelium. |
| Function | Participates in the Wnt signaling pathway. Binds to DNA and acts as a repressor in the absence of CTNNB1, and as an activator in its presence. Necessary for the terminal differentiation of epidermal cells, the formation of keratohyalin granules and the development of the barrier function of the epidermis. Down-regulates NQO1, leading to increased mitomycin c resistance. |
| Protein Name | Transcription Factor 7-Like 1Hmg Box Transcription Factor 3Tcf-3 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-8951430Reactome: R-HSA-9825892Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor 7-Like 1 antibodyAnti-Hmg Box Transcription Factor 3 antibodyAnti-Tcf-3 antibodyAnti-TCF7L1 antibodyAnti-TCF3 antibody |
Information sourced from Uniprot.org