Anti-TRAFD1 antibody (1-260) (STJ115040)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TRAFD1 (1-260) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRAFD1 |
| Gene ID | 10906 |
| Uniprot ID | TRAD1_HUMAN |
| Immunogen Region | 1-260 |
| Immunogen Sequence | MAEFLDDQETRLCDNCKKEI PVFNFTIHEIHCQRNIGMCP TCKEPFPKSDMETHMAAEHC QVTCKCNKKLEKRLLKKHEE TECPLRLAVCQHCDLELSIL KLKEHEDYCGARTELCGNCG RNVLVKDLKTHPEVCGREGE EKRNEVAIPPNAYDESWGQD GIWIASQLLRQIEALDPPMR LPRRPLRAFESDVFHNRTTN QRNITAQVSIQNNLFEEQER QERNRGQQPPKEGGEESAN |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human TRAFD1 (NP_006691.1). |
Additional Info
| Function | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. |
| Protein Name | Traf-Type Zinc Finger Domain-Containing Protein 1Protein Fln29 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-Traf-Type Zinc Finger Domain-Containing Protein 1 antibodyAnti-Protein Fln29 antibodyAnti-TRAFD1 antibodyAnti-FLN29 antibody |
Information sourced from Uniprot.org