| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TRAFD1 |
| Gene ID: | 10906 |
| Uniprot ID: | TRAD1_HUMAN |
| Immunogen Region: | 1-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human TRAFD1 (NP_006691.1). |
| Immunogen Sequence: | MAEFLDDQETRLCDNCKKEI PVFNFTIHEIHCQRNIGMCP TCKEPFPKSDMETHMAAEHC QVTCKCNKKLEKRLLKKHEE TECPLRLAVCQHCDLELSIL KLKEHEDYCGARTELCGNCG RNVLVKDLKTHPEVCGREGE EKRNEVAIPPNAYDESWGQD GIWIASQLLRQIEALDPPMR LPRRPLRAFESDVFHNRTTN QRNITAQVSIQNNLFEEQER QERNRGQQPPKEGGEESAN |
| Function | Negative feedback regulator that controls excessive innate immune responses. Regulates both Toll-like receptor 4 (TLR4) and DDX58/RIG1-like helicases (RLH) pathways. May inhibit the LTR pathway by direct interaction with TRAF6 and attenuation of NF-kappa-B activation. May negatively regulate the RLH pathway downstream from MAVS and upstream of NF-kappa-B and IRF3. |
| Protein Name | Traf-Type Zinc Finger Domain-Containing Protein 1Protein Fln29 |
| Alternative Antibody Names | Anti-Traf-Type Zinc Finger Domain-Containing Protein 1 antibodyAnti-Protein Fln29 antibodyAnti-TRAFD1 antibodyAnti-FLN29 antibody |
Information sourced from Uniprot.org