| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-RFTN1 (1-260) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
RFTN1 |
| Gene ID: |
23180 |
| Uniprot ID: |
RFTN1_HUMAN |
| Immunogen Region: |
1-260 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human RFTN1 (NP_055965.1). |
| Immunogen Sequence: |
MGCGLNKLEKRDEKRPGNIY STLKRPQVETKIDVSYEYRF LEFTTLSAAELPGSSAVRLA SLRDLPAQLLELYQQGFSLA ALHPFVQPTHEREKTPLEHI FRAILIKKTDRSQKTDLHNE GYILELDCCSSLDHPTDQKL IPEFIKKIQEAASQGLKFVG VIPQYHSSVNSAGSSAPVST ANSTEDARDAKNARGDHASL ENEKPGTGDVCSAPAGRNQS PEPSSGPRGEVPLAKQPSS |
| Tissue Specificity | Expressed in B-cells (at protein level). Expressed in dendritic cells and macrophages. |
| Function | Involved in protein trafficking via association with clathrin and AP2 complex. Upon bacterial lipopolysaccharide stimulation, mediates internalization of TLR4 to endosomes in dendritic cells and macrophages.and internalization of poly(I:C) to TLR3-positive endosomes in myeloid dendritic cells and epithelial cells.resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. Involved in T-cell antigen receptor-mediated signaling by regulating tyrosine kinase LCK localization, T-cell dependent antibody production and cytokine secretion. May regulate B-cell antigen receptor-mediated signaling. May play a pivotal role in the formation and/or maintenance of lipid rafts. |
| Protein Name | RaftlinCell Migration-Inducing Gene 2 ProteinRaft-Linking Protein |
| Cellular Localisation | Cell MembraneLipid-AnchorCytoplasmMembrane RaftEndosomeEarly EndosomeTranslocates From Cytoplasm To Cell Membrane Where It Colocalizes With Poly (I:c) And Then Moves To Endosomes Where It Colocalizes With Tlr3Translocates From Cytoplasm To Cell Membrane Where It Colocalizes With Tlr4 And Then Together With Tlr4 Moves To EndosomesUpon Lipopolysaccharide Stimulation |
| Alternative Antibody Names | Anti-Raftlin antibodyAnti-Cell Migration-Inducing Gene 2 Protein antibodyAnti-Raft-Linking Protein antibodyAnti-RFTN1 antibodyAnti-KIAA0084 antibodyAnti-MIG2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
