Anti-TRAF3IP2 antibody (N-Term) (STJA0005689)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthetic peptide corresponding to amino acids from the N-terminal region of human ACT protein
General Information
| Short Description | Rabbit polyclonal anti-ACT (N-Term) for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Antigen Affinity Purified |
| Dilution Range | WB 1:500-1:1000 |
| Formulation | PBS + 0.02% NaN3 |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRAF3IP2 |
| Gene ID | 10758 |
| Uniprot ID | CIKS_HUMAN |
| Immunogen | Synthetic peptide corresponding to amino acids from the N-terminal region of human ACT protein |
| Immunogen Region | N-Term |
| Specificity | Reacts with the N-terminal region of human ACT protein |
Additional Info
| Function | E3 ubiquitin ligase that catalyzes 'Lys-63'-linked polyubiquitination of target protein, enhancing protein-protein interaction and cell signaling. Transfers ubiquitin from E2 ubiquitin-conjugating enzyme UBE2V1-UBE2N to substrate protein. Essential adapter molecule in IL17A-mediated signaling. Upon IL17A stimulation, interacts with IL17RA and IL17RC receptor chains through SEFIR domains and catalyzes 'Lys-63'-linked polyubiquitination of TRAF6, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways. |
| Protein Name | E3 Ubiquitin Ligase Traf3ip2Adapter Protein CiksConnection To Ikk And Sapk/JnkE3 Ubiquitin-Protein Ligase CiksNuclear Factor Nf-Kappa-B Activator 1Act1Traf3-Interacting Protein 2 |
| Database Links | |
| Cellular Localisation | |
| Alternative Antibody Names | Anti-E3 Ubiquitin Ligase Traf3ip2 antibodyAnti-Adapter Protein Ciks antibodyAnti-Connection To Ikk And Sapk/Jnk antibodyAnti-E3 Ubiquitin-Protein Ligase Ciks antibodyAnti-Nuclear Factor Nf-Kappa-B Activator 1 antibodyAnti-Act1 antibodyAnti-Traf3-Interacting Protein 2 antibodyAnti-TRAF3IP2 antibodyAnti-C6orf2 antibodyAnti-C6orf4 antibodyAnti-C6orf5 antibodyAnti-C6orf6 antibody |
Information sourced from Uniprot.org