Anti-TRA2B antibody (STJA0008590)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TRA2B
General Information
| Short Description | Rabbit polyclonal anti-Transformer-2 protein homolog beta for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TRA2B |
| Gene ID | 6434 |
| Uniprot ID | TRA2B_HUMAN |
| Immunogen | Synthesized peptide derived from human TRA2B |
| Specificity | This antibody detects endogenous levels of TRA2B at Human, Mouse, Rat |
Additional Info
| Post Translational Modifications | Phosphorylated in the RS domains. Dimethylation at Arg-241 is probably asymmetric. |
| Function | Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA. |
| Protein Name | Transformer-2 Protein Homolog BetaTra-2 BetaTra2-BetaHtra2-BetaSplicing Factor - Arginine/Serine-Rich 10Transformer-2 Protein Homolog B |
| Database Links | Reactome: R-HSA-72163Reactome: R-HSA-72203Reactome: R-HSA-9013418Reactome: R-HSA-9013422 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transformer-2 Protein Homolog Beta antibodyAnti-Tra-2 Beta antibodyAnti-Tra2-Beta antibodyAnti-Htra2-Beta antibodyAnti-Splicing Factor - Arginine/Serine-Rich 10 antibodyAnti-Transformer-2 Protein Homolog B antibodyAnti-TRA2B antibodyAnti-SFRS10 antibody |
Information sourced from Uniprot.org