Anti-TPX2 antibody [TPX2-01] (STJ16103406)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenHuman TPX2
General Information
| Short Description | Mouse monoclonal anti-TPX2 for use in IP, WB, IHC-P, ICC and ELISA in Rat, Mouse and Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IP/WB/IHC-P/ICC/ELISA |
| Host | Mouse |
| Reactivity | Rat/Mouse/Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | TPX2-01 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | TPX2 |
| Gene ID | 22974 |
| Uniprot ID | TPX2_HUMAN |
| Immunogen | Human TPX2 |
Additional Info
| Function | Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activate AURKA kinase and stimulate local microtubule nucleation. |
| Protein Name | Targeting Protein For Xklp2Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2Dil-2Hepatocellular Carcinoma-Associated Antigen 519Hepatocellular Carcinoma-Associated Antigen 90Protein Fls353Restricted Expression Proliferation-Associated Protein 100P100 |
| Database Links | Reactome: R-HSA-6804756Reactome: R-HSA-8854518 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonSpindleSpindle PoleDuring Mitosis It Is Strictly Associated With The Spindle Pole And With The Mitotic SpindleWhereas During S And G2It Is Diffusely Distributed Throughout The NucleusIs Released From The Nucleus In Apoptotic Cells And Is Detected On Apoptotic Microtubules |
| Alternative Antibody Names | Anti-Targeting Protein For Xklp2 antibodyAnti-Differentially Expressed In Cancerous And Non-Cancerous Lung Cells 2 antibodyAnti-Dil-2 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 519 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 90 antibodyAnti-Protein Fls353 antibodyAnti-Restricted Expression Proliferation-Associated Protein 100 antibodyAnti-P100 antibodyAnti-TPX2 antibodyAnti-C20orf1 antibodyAnti-C20orf2 antibodyAnti-DIL2 antibodyAnti-HCA519 antibody |
Information sourced from Uniprot.org