Anti-TPSAB1 antibody (200-275 aa) [ABT-MCT] (STJ196843)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenSynthesized peptide derived from the human Mast cell tryptase at the amino acid range 200-275
General Information
| Short Description | Mouse monoclonal anti-Tryptase alpha/beta-1 (200-275 aa) for use in IHC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ABT-MCT |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC-P 1:100-500IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TPSAB1 |
| Gene ID | 7177 |
| Uniprot ID | TRYB1_HUMAN |
| Immunogen | Synthesized peptide derived from the human Mast cell tryptase at the amino acid range 200-275 |
| Immunogen Region | 200-275 aa |
| Specificity | This antibody detects endogenous levels of human Mast cell tryptase. Heat-induced epitope retrieval (HIER) Citrate buffer of pH6.0 was highly recommended as antigen repair method in paraffin section. |
Additional Info
| Function | Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. May play a role in innate immunity. Isoform 2 cleaves large substrates, such as fibronectin, more efficiently than isoform 1, but seems less efficient toward small substrates. |
| Protein Name | Tryptase Alpha/Beta-1Tryptase-1Tryptase ITryptase Alpha-1 |
| Database Links | Reactome: R-HSA-1592389 |
| Cellular Localisation | SecretedReleased From The Secretory Granules Upon Mast Cell Activation |
| Alternative Antibody Names | Anti-Tryptase Alpha/Beta-1 antibodyAnti-Tryptase-1 antibodyAnti-Tryptase I antibodyAnti-Tryptase Alpha-1 antibodyAnti-TPSAB1 antibodyAnti-TPS1 antibodyAnti-TPS2 antibodyAnti-TPSB1 antibody |
Information sourced from Uniprot.org