| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TPP1 (284-563) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TPP1 |
| Gene ID: |
1200 |
| Uniprot ID: |
TPP1_HUMAN |
| Immunogen Region: |
284-563 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 284-563 of human TPP1 (NP_000382.3). |
| Immunogen Sequence: |
GANISTWVYSSPGRHEGQEP FLQWLMLLSNESALPHVHTV SYGDDEDSLSSAYIQRVNTE LMKAAARGLTLLFASGDSGA GCWSVSGRHQFRPTFPASSP YVTTVGGTSFQEPFLITNEI VDYISGGGFSNVFPRPSYQE EAVTKFLSSSPHLPPSSYFN ASGRAYPDVAALSDGYWVVS NRVPIPWVSGTSASTPVFGG ILSLINEHRILSGRPPLGFL NPRLYQQHGAGLFDVTRGC |
| Tissue Specificity | Detected in all tissues examined with highest levels in heart and placenta and relatively similar levels in other tissues. |
| Post Translational Modifications | Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity. |
| Function | Lysosomal serine protease with tripeptidyl-peptidase I activity. May act as a non-specific lysosomal peptidase which generates tripeptides from the breakdown products produced by lysosomal proteinases. Requires substrates with an unsubstituted N-terminus. |
| Protein Name | Tripeptidyl-Peptidase 1Tpp-1Cell Growth-Inhibiting Gene 1 ProteinLysosomal Pepstatin-Insensitive ProteaseLpicTripeptidyl AminopeptidaseTripeptidyl-Peptidase ITpp-I |
| Database Links | Reactome: R-HSA-381038 |
| Cellular Localisation | LysosomeMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv |
| Alternative Antibody Names | Anti-Tripeptidyl-Peptidase 1 antibodyAnti-Tpp-1 antibodyAnti-Cell Growth-Inhibiting Gene 1 Protein antibodyAnti-Lysosomal Pepstatin-Insensitive Protease antibodyAnti-Lpic antibodyAnti-Tripeptidyl Aminopeptidase antibodyAnti-Tripeptidyl-Peptidase I antibodyAnti-Tpp-I antibodyAnti-TPP1 antibodyAnti-CLN2 antibodyAnti-GIG1 antibodyAnti-UNQ267 antibodyAnti-PRO304 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
