Anti-TPCN1 antibody (104-154 aa) (STJ195679)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TPC1 at the amino acid range 104-154
General Information
| Short Description | Rabbit polyclonal anti-Two pore channel protein 1 (104-154 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TPCN1 |
| Gene ID | 53373 |
| Uniprot ID | TPC1_HUMAN |
| Immunogen | Synthesized peptide derived from the human TPC1 at the amino acid range 104-154 |
| Immunogen Region | 104-154 aa |
| Specificity | This antibody detects endogenous levels of TPC1 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | N-glycosylated. |
| Function | Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles. Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable). (Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm. |
| Protein Name | Two Pore Channel Protein 1Two Pore Calcium Channel Protein 1Voltage-Dependent Calcium Channel Protein Tpc1 |
| Database Links | Reactome: R-HSA-2672351 |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinEndosome MembraneEarly Endosome MembraneRecycling Endosome Membrane |
| Alternative Antibody Names | Anti-Two Pore Channel Protein 1 antibodyAnti-Two Pore Calcium Channel Protein 1 antibodyAnti-Voltage-Dependent Calcium Channel Protein Tpc1 antibodyAnti-TPCN1 antibodyAnti-KIAA1169 antibodyAnti-TPC1 antibody |
Information sourced from Uniprot.org