| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-TP63 (Full length) is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 4A4 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2a/Kappa |
| Formulation: | Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin |
| Purification: | Affinity purified |
| Dilution Range: | 1:100-200 |
| Storage Instruction: | Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C. |
| Gene Symbol: | TP63 |
| Gene ID: | 8626 |
| Uniprot ID: | P63_HUMAN |
| Immunogen Region: | Full length |
| Specificity: | Positive control: Skin or prostate |
| Immunogen: | Recombinant full-length human p63 protein |
| Tissue Specificity | Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues. |
| Post Translational Modifications | May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. |
| Function | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. |
| Protein Name | Tumor Protein 63 P63 Chronic Ulcerative Stomatitis Protein Cusp Keratinocyte Transcription Factor Ket Transformation-Related Protein 63 Tp63 Tumor Protein P73-Like P73l P40 P51 |
| Database Links | Reactome: R-HSA-139915 Reactome: R-HSA-5620971 Reactome: R-HSA-5628897 Reactome: R-HSA-6803204 Reactome: R-HSA-6803205 Reactome: R-HSA-6803207 Reactome: R-HSA-6803211 Reactome: R-HSA-6804759 Reactome: R-HSA-9725554 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Tumor Protein 63 antibody Anti-P63 antibody Anti-Chronic Ulcerative Stomatitis Protein antibody Anti-Cusp antibody Anti-Keratinocyte Transcription Factor Ket antibody Anti-Transformation-Related Protein 63 antibody Anti-Tp63 antibody Anti-Tumor Protein P73-Like antibody Anti-P73l antibody Anti-P40 antibody Anti-P51 antibody Anti-TP63 antibody Anti-KET antibody Anti-P63 antibody Anti-P73H antibody Anti-P73L antibody Anti-TP73L antibody |
Information sourced from Uniprot.org