Anti-TP63 antibody (1-100 aa) [ABT020] (STJ197094)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2bk
ImmunogenSynthesized peptide derived from the human p40 (DeltaNp63) at the amino acid range 1-100
General Information
| Short Description | Mouse monoclonal anti-Tumor protein 63 (1-100 aa) for use in IHC, WB and IF in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB/IF |
| Host | Mouse |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | ABT020 |
| Isotype | IgG2bk |
| Conjugation | Unconjugated |
| Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range | IHC-P 1:100-500WB 1:200-1000IF 1:100-500 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TP63 |
| Gene ID | 8626 |
| Uniprot ID | P63_HUMAN |
| Immunogen | Synthesized peptide derived from the human p40 (DeltaNp63) at the amino acid range 1-100 |
| Immunogen Region | 1-100 aa |
| Specificity | The antibody can specifically recognize human P40 ( Delta Np63) protein, and TAp63 dose not respond.. The antibody was also Predict react with Mouse |
Additional Info
| Post Translational Modifications | May be sumoylated. Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein. |
| Function | Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter. |
| Protein Name | Tumor Protein 63P63Chronic Ulcerative Stomatitis ProteinCuspKeratinocyte Transcription Factor KetTransformation-Related Protein 63Tp63Tumor Protein P73-LikeP73lP40P51 |
| Database Links | Reactome: R-HSA-139915Reactome: R-HSA-5620971Reactome: R-HSA-5628897Reactome: R-HSA-6803204Reactome: R-HSA-6803205Reactome: R-HSA-6803207Reactome: R-HSA-6803211Reactome: R-HSA-6804759Reactome: R-HSA-9725554 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Tumor Protein 63 antibodyAnti-P63 antibodyAnti-Chronic Ulcerative Stomatitis Protein antibodyAnti-Cusp antibodyAnti-Keratinocyte Transcription Factor Ket antibodyAnti-Transformation-Related Protein 63 antibodyAnti-Tp63 antibodyAnti-Tumor Protein P73-Like antibodyAnti-P73l antibodyAnti-P40 antibodyAnti-P51 antibodyAnti-TP63 antibodyAnti-KET antibodyAnti-P63 antibodyAnti-P73H antibodyAnti-P73L antibodyAnti-TP73L antibody |
Information sourced from Uniprot.org