Anti-TP53RK antibody (STJA0008343)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TP53RK
General Information
| Short Description | Rabbit polyclonal anti-EKC/KEOPS complex subunit TP53RK for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TP53RK |
| Gene ID | 112858 |
| Uniprot ID | PRPK_HUMAN |
| Immunogen | Synthesized peptide derived from human TP53RK |
| Specificity | This antibody detects endogenous levels of TP53RK at Human, Mouse |
Additional Info
| Function | Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP. Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation. |
| Protein Name | Ekc/Keops Complex Subunit Tp53rkAtypical Serine/Threonine Protein Kinase Tp53rkNori-2Tp53-Regulating KinaseP53-Related Protein Kinase |
| Database Links | Reactome: R-HSA-6782315Reactome: R-HSA-6804756 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ekc/Keops Complex Subunit Tp53rk antibodyAnti-Atypical Serine/Threonine Protein Kinase Tp53rk antibodyAnti-Nori-2 antibodyAnti-Tp53-Regulating Kinase antibodyAnti-P53-Related Protein Kinase antibodyAnti-TP53RK antibodyAnti-C20orf64 antibodyAnti-PRPK antibody |
Information sourced from Uniprot.org