• Immunohistochemistry analysis of paraffin-embedded mouse brain using TP53BP2 antibody (STJ27671) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human gastric cancer using TP53BP2 antibody (STJ27671) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded rat brain using TP53BP2 antibody (STJ27671) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.

Anti-TP53BP2 antibody (360-600) (STJ27671)

SKU:
STJ27671

£169.50 - £449.50
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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TP53BP2 (360-600) is suitable for use in Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TP53BP2
Gene ID: 7159
Uniprot ID: ASPP2_HUMAN
Immunogen Region: 360-600
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 360-600 of human TP53BP2 (NP_001026855.2).
Immunogen Sequence: STMPRMPSRPELLVKPALPD GSLVIQASEGPMKIQTLPNM RSGAASQTKGSKIHPVGPDW SPSNADLFPSQGSASVPQST GNALDQVDDGEVPLREKEKK VRPFSMFDAVDQSNAPPSFG TLRKNQSSEDILRDAQVANK NVAKVPPPVPTKPKQINLPY FGQTNQPPSDIKPDGSSQQL STVVPSMGTKPKPAGQQPRV LLSPSIPSVGQDQTLSPGSK QESPPAAAVRPFTPQPSKD
Tissue Specificity Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocyte. Reduced expression in breast carcinomas expressing a wild-type TP53 protein. Overexpressed in lung cancer cell lines.
Function Regulator that plays a central role in regulation of apoptosis and cell growth via its interactions with proteins such as TP53. Regulates TP53 by enhancing the DNA binding and transactivation function of TP53 on the promoters of proapoptotic genes in vivo. Inhibits the ability of NAE1 to conjugate NEDD8 to CUL1, and thereby decreases NAE1 ability to induce apoptosis. Impedes cell cycle progression at G2/M. Its apoptosis-stimulating activity is inhibited by its interaction with DDX42.
Protein Name Apoptosis-Stimulating Of P53 Protein 2
Bcl2-Binding Protein
Bbp
Renal Carcinoma Antigen Ny-Ren-51
Tumor Suppressor P53-Binding Protein 2
53bp2
P53-Binding Protein 2
P53bp2
Database Links Reactome: R-HSA-139915
Reactome: R-HSA-6803204
Reactome: R-HSA-6803205
Reactome: R-HSA-6803211
Reactome: R-HSA-6804759
Cellular Localisation Cytoplasm
Perinuclear Region
Nucleus
Predominantly Found In The Perinuclear Region
Some Small Fraction Is Nuclear
Sequester In The Cytoplasm On Overexpression Of Ddx42
Alternative Antibody Names Anti-Apoptosis-Stimulating Of P53 Protein 2 antibody
Anti-Bcl2-Binding Protein antibody
Anti-Bbp antibody
Anti-Renal Carcinoma Antigen Ny-Ren-51 antibody
Anti-Tumor Suppressor P53-Binding Protein 2 antibody
Anti-53bp2 antibody
Anti-P53-Binding Protein 2 antibody
Anti-P53bp2 antibody
Anti-TP53BP2 antibody
Anti-ASPP2 antibody
Anti-BBP antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance