Anti-TOR1A antibody (63-332) (STJ25925)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TOR1A (63-332) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TOR1A |
| Gene ID | 1861 |
| Uniprot ID | TOR1A_HUMAN |
| Immunogen Region | 63-332 |
| Immunogen Sequence | KDLDDNLFGQHLAKKIILNA VFGFINNPKPKKPLTLSLHG WTGTGKNFVSKIIAENIYEG GLNSDYVHLFVATLHFPHAS NITLYKDQLQLWIRGNVSAC ARSIFIFDEMDKMHAGLIDA IKPFLDYYDLVDGVSYQKAM FIFLSNAGAERITDVALDFW RSGKQREDIKLKDIEHALSV SVFNNKNSGFWHSSLIDRNL IDYFVPFLPLEYKHLKMCIR VEMQSRGYEIDEDIVSRVA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 63-332 of human TorsinA/TOR1A (NP_000104.1). |
Additional Info
| Tissue Specificity | Widely expressed. Highest levels in kidney and liver. In the brain, high levels found in the dopaminergic neurons of the substantia nigra pars compacta, as well as in the neocortex, hippocampus and cerebellum. Also highly expressed in the spinal cord. |
| Post Translational Modifications | N-glycosylated. |
| Function | Protein with chaperone functions important for the control of protein folding, processing, stability and localization as well as for the reduction of misfolded protein aggregates. Involved in the regulation of synaptic vesicle recycling, controls STON2 protein stability in collaboration with the COP9 signalosome complex (CSN). In the nucleus, may link the cytoskeleton with the nuclear envelope, this mechanism seems to be crucial for the control of nuclear polarity, cell movement and, specifically in neurons, nuclear envelope integrity. Participates in the cellular trafficking and may regulate the subcellular location of multipass membrane proteins such as the dopamine transporter SLC6A3, leading to the modulation of dopamine neurotransmission. In the endoplasmic reticulum, plays a role in the quality control of protein folding by increasing clearance of misfolded proteins such as SGCE variants or holding them in an intermediate state for proper refolding. May have a redundant function with TOR1B in non-neural tissues. |
| Protein Name | Torsin-1aDystonia 1 ProteinTorsin Atpase-1aTorsin Family 1 Member A |
| Database Links | Reactome: R-HSA-8856825 |
| Cellular Localisation | Endoplasmic Reticulum LumenNucleus MembranePeripheral Membrane ProteinCell ProjectionGrowth ConeCytoplasmic Vesicle MembraneCytoplasmic VesicleSecretory VesicleSynaptic VesicleCytoplasmCytoskeletonUpon Oxidative StressRedistributes To Protusions From The Cell SurfacePeripherally Associated With The Inner Face Of The Er MembraneProbably Mediated By The Interaction With Tor1aip1The Association With Nucleus Membrane Is Mediated By The Interaction With Tor1aip2 |
| Alternative Antibody Names | Anti-Torsin-1a antibodyAnti-Dystonia 1 Protein antibodyAnti-Torsin Atpase-1a antibodyAnti-Torsin Family 1 Member A antibodyAnti-TOR1A antibodyAnti-DQ2 antibodyAnti-DYT1 antibodyAnti-TA antibodyAnti-TORA antibody |
Information sourced from Uniprot.org