Anti-TOMM70 antibody (245-608) (STJ25915)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TOM70 (245-608) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TOMM70 |
| Gene ID | 9868 |
| Uniprot ID | TOM70_HUMAN |
| Immunogen Region | 245-608 |
| Immunogen Sequence | KNREPLMPSPQFIKSYFSSF TDDIISQPMLKGEKSDEDKD KEGEALEVKENSGYLKAKQY MEEENYDKIISECSKEIDAE GKYMAEALLLRATFYLLIGN ANAAKPDLDKVISLKEANVK LRANALIKRGSMYMQQQQPL LSTQDFNMAADIDPQNADVY HHRGQLKILLDQVEEAVADF DECIRLRPESALAQAQKCFA LYRQAYTGNNSSQIQAAMKG FEEVIKKFPRCAEGYALYA |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 245-608 of human TOM70 (NP_055635.3). |
Additional Info
| Function | Acts as a receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner. Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection. Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis. |
| Protein Name | Mitochondrial Import Receptor Subunit Tom70Mitochondrial Precursor Proteins Import ReceptorTranslocase Of Outer Membrane 70 Kda SubunitTranslocase Of Outer Mitochondrial Membrane Protein 70 |
| Database Links | Reactome: R-HSA-1268020Reactome: R-HSA-168928Reactome: R-HSA-5205685Reactome: R-HSA-5689880Reactome: R-HSA-9692916Reactome: R-HSA-9705671 |
| Cellular Localisation | Mitochondrion Outer MembraneSingle-Pass Membrane Protein(Microbial Infection) During Parasite TGondii-Mediated InfectionEnriched At The Interface Between The Host Mitochondria And The Parasitopharous Vacuole |
| Alternative Antibody Names | Anti-Mitochondrial Import Receptor Subunit Tom70 antibodyAnti-Mitochondrial Precursor Proteins Import Receptor antibodyAnti-Translocase Of Outer Membrane 70 Kda Subunit antibodyAnti-Translocase Of Outer Mitochondrial Membrane Protein 70 antibodyAnti-TOMM70 antibodyAnti-KIAA0719 antibodyAnti-TOM70 antibodyAnti-TOMM70A antibody |
Information sourced from Uniprot.org