| Applications: | WB/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNRC6A |
| Gene ID: | 27327 |
| Uniprot ID: | TNR6A_HUMAN |
| Immunogen Region: | 950-1050 |
| Immunogen Sequence: | QDIVGSWGIPPATGKPPGTG WLGGPIPAPAKEEEPTGWEE PSPESIRRKMEIDDGTSAWG DPSKYNYKNVNMWNKNVPNG NSRSDQQAQVHQLLTPASAI S |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 950-1050 of human TNRC6A (NP_055309.2). |
| Tissue Specificity | Ubiquitous. |
| Function | Plays a role in RNA-mediated gene silencing by both micro-RNAs (miRNAs) and short interfering RNAs (siRNAs). Required for miRNA-dependent repression of translation and for siRNA-dependent endonucleolytic cleavage of complementary mRNAs by argonaute family proteins. As a scaffolding protein, associates with argonaute proteins bound to partially complementary mRNAs, and can simultaneously recruit CCR4-NOT and PAN deadenylase complexes. |
| Protein Name | Trinucleotide Repeat-Containing Gene 6a ProteinCag Repeat Protein 26Emsy Interactor ProteinGw182 AutoantigenProtein Gw1Glycine-Tryptophan Protein Of 182 Kda |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-4086398Reactome: R-HSA-426496Reactome: R-HSA-5578749Reactome: R-HSA-5628897Reactome: R-HSA-5687128Reactome: R-HSA-8853884Reactome: R-HSA-8934593Reactome: R-HSA-8936459Reactome: R-HSA-8943723Reactome: R-HSA-8948700Reactome: R-HSA-8986944Reactome: R-HSA-9018519Reactome: R-HSA-9022692Reactome: R-HSA-9029569Reactome: R-HSA-9759811Reactome: R-HSA-9768778Reactome: R-HSA-9824594Reactome: R-HSA-9839394 |
| Cellular Localisation | CytoplasmP-BodyMammalian P-Bodies Are Also Known As Gw Bodies (Gwbs) |
| Alternative Antibody Names | Anti-Trinucleotide Repeat-Containing Gene 6a Protein antibodyAnti-Cag Repeat Protein 26 antibodyAnti-Emsy Interactor Protein antibodyAnti-Gw182 Autoantigen antibodyAnti-Protein Gw1 antibodyAnti-Glycine-Tryptophan Protein Of 182 Kda antibodyAnti-TNRC6A antibodyAnti-CAGH26 antibodyAnti-KIAA1460 antibodyAnti-TNRC6 antibody |
Information sourced from Uniprot.org
