Anti-TNPO3 antibody [R07-3X3] (STJA0036955)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human TNPO3
General Information
| Short Description | Rabbit monoclonal anti-TNPO3 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R07-3X3 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:50-1:100IF 1:50-1:200 |
| Formulation | Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | TNPO3 |
| Gene ID | 23534 |
| Uniprot ID | TNPO3_HUMAN |
| Immunogen | A synthesized peptide derived from human TNPO3 |
Additional Info
| Tissue Specificity | Expressed in skeletal muscle. |
| Function | Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus. (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus. Required for a nuclear maturation step of HIV-1 prior to integration. |
| Protein Name | Transportin-3Importin-12Imp12Transportin-SrTrn-Sr |
| Database Links | |
| Cellular Localisation | Nucleus EnvelopeCytoplasmLocalizes To The Nuclear Envelope And Annulate LamellaeWhich Consists In Stacks Of Endoplasmic Reticulum Membranes Containing A High Density Of Nuclear Pores |
| Alternative Antibody Names | Anti-Transportin-3 antibodyAnti-Importin-12 antibodyAnti-Imp12 antibodyAnti-Transportin-Sr antibodyAnti-Trn-Sr antibodyAnti-TNPO3 antibodyAnti-IPO12 antibody |
Information sourced from Uniprot.org