Anti-TNKS antibody (STJ192373)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Poly polymerase tankyrase-1 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNKS |
| Gene ID | 8658 |
| Uniprot ID | TNKS1_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | TNKS1 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. Phosphorylated during mitosis. Ubiquitinated by RNF146 when auto-poly-ADP-ribosylated, leading to its degradation. Deubiquitinated by USP25.leading to stabilization. ADP-ribosylated (-auto). Poly-ADP-ribosylated protein is recognized by RNF146, followed by ubiquitination. |
| Function | Poly-ADP-ribosyltransferase involved in various processes such as Wnt signaling pathway, telomere length and vesicle trafficking. Acts as an activator of the Wnt signaling pathway by mediating poly-ADP-ribosylation (PARsylation) of AXIN1 and AXIN2, 2 key components of the beta-catenin destruction complex: poly-ADP-ribosylated target proteins are recognized by RNF146, which mediates their ubiquitination and subsequent degradation. Also mediates PARsylation of BLZF1 and CASC3, followed by recruitment of RNF146 and subsequent ubiquitination. Mediates PARsylation of TERF1, thereby contributing to the regulation of telomere length. Involved in centrosome maturation during prometaphase by mediating PARsylation of HEPACAM2/MIKI. May also regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. May be involved in spindle pole assembly through PARsylation of NUMA1. Stimulates 26S proteasome activity. |
| Protein Name | Poly Adp-Ribose Polymerase Tankyrase-1Adp-Ribosyltransferase Diphtheria Toxin-Like 5Artd5Poly Adp-Ribose Polymerase 5aProtein Poly-Adp-Ribosyltransferase Tankyrase-1Tnks-1Trf1-Interacting Ankyrin-Related Adp-Ribose PolymeraseTankyrase ITankyrase-1Tank1 |
| Database Links | Reactome: R-HSA-201681Reactome: R-HSA-4641257Reactome: R-HSA-5545619Reactome: R-HSA-5689880Reactome: R-HSA-8948751 |
| Cellular Localisation | CytoplasmGolgi Apparatus MembranePeripheral Membrane ProteinCytoskeletonMicrotubule Organizing CenterCentrosomeNucleusNuclear Pore ComplexChromosomeTelomereSpindle PoleAssociated With The Golgi And With Juxtanuclear Slc2a4/Glut4-VesiclesA Minor Proportion Is Also Found At Nuclear Pore Complexes And Around The Pericentriolar Matrix Of Mitotic CentromeresDuring InterphaseA Small Fraction Of Tnks Is Found In The NucleusAssociated With Terf1Localizes To Spindle Poles At Mitosis Onset Via Interaction With Numa1 |
| Alternative Antibody Names | Anti-Poly Adp-Ribose Polymerase Tankyrase-1 antibodyAnti-Adp-Ribosyltransferase Diphtheria Toxin-Like 5 antibodyAnti-Artd5 antibodyAnti-Poly Adp-Ribose Polymerase 5a antibodyAnti-Protein Poly-Adp-Ribosyltransferase Tankyrase-1 antibodyAnti-Tnks-1 antibodyAnti-Trf1-Interacting Ankyrin-Related Adp-Ribose Polymerase antibodyAnti-Tankyrase I antibodyAnti-Tankyrase-1 antibodyAnti-Tank1 antibodyAnti-TNKS antibodyAnti-PARP5A antibodyAnti-PARPL antibodyAnti-TIN1 antibodyAnti-TINF1 antibodyAnti-TNKS1 antibody |
Information sourced from Uniprot.org