Anti-TNK1 antibody (600-666) {Biotin} (STJ506150)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationBiotin
IsotypeIgG
ImmunogenSynthetic peptide taken within amino acid region 600-666 on human Non-receptor tyrosine-protein kinase TNK1.
General Information
| Short Description | Rabbit polyclonal antibody anti-TNK1 (600-666) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Biotin |
| Concentration | 0.5-1.5 µg/µl |
| Purification | Affinity Purified |
| Dilution Range | WB: 1:500-1:5, 000ELISA: 1:50, 000IP: 1:200 |
| Formulation | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Storage Instruction | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TNK1 |
| Gene ID | 8711 |
| Uniprot ID | TNK1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 600-666 on human Non-receptor tyrosine-protein kinase TNK1. |
| Immunogen Region | 600-666 |
Additional Info
| Tissue Specificity | Expressed in all umbilical cord blood, bone marrow and adult blood cell sub-populations and in several leukemia cell lines. Highly expressed in fetal blood, brain, lung, liver and kidney. Detected at lower levels in adult prostate, testis, ovary, small intestine and colon. Not expressed in adult lung, liver, kidney or brain. |
| Post Translational Modifications | Autophosphorylated on tyrosine residues. |
| Function | Involved in negative regulation of cell growth. Has tumor suppressor properties. Plays a negative regulatory role in the Ras-MAPK pathway. May function in signaling pathways utilized broadly during fetal development and more selectively in adult tissues and in cells of the lymphohematopoietic system. Could specifically be involved in phospholipid signal transduction. |
| Protein Name | Non-Receptor Tyrosine-Protein Kinase Tnk1Cd38 Negative Kinase 1 |
| Cellular Localisation | CytoplasmMembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Non-Receptor Tyrosine-Protein Kinase Tnk1 antibodyAnti-Cd38 Negative Kinase 1 antibodyAnti-TNK1 antibody |
Information sourced from Uniprot.org