Anti-TNIK antibody (350-430 aa) (STJ190403)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 350-430
General Information
| Short Description | Rabbit polyclonal anti-TRAF2 and NCK-interacting protein kinase (350-430 aa) for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNIK |
| Gene ID | 23043 |
| Uniprot ID | TNIK_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 350-430 |
| Immunogen Region | 350-430 aa |
| Specificity | TNIK Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autophosphorylated. Autophosphorylation is activated by RAP2A and induces association to the cytoskeletal fraction. |
| Function | Serine/threonine kinase that acts as an essential activator of the Wnt signaling pathway. Recruited to promoters of Wnt target genes and required to activate their expression. May act by phosphorylating TCF4/TCF7L2. Appears to act upstream of the JUN N-terminal pathway. May play a role in the response to environmental stress. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. More generally, it may play a role in cytoskeletal rearrangements and regulate cell spreading. Phosphorylates SMAD1 on Thr-322. Activator of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. MAP4Ks act in parallel to and are partially redundant with STK3/MST2 and STK4/MST2 in the phosphorylation and activation of LATS1/2, and establish MAP4Ks as components of the expanded Hippo pathway. |
| Protein Name | Traf2 And Nck-Interacting Protein Kinase |
| Database Links | Reactome: R-HSA-2559580 |
| Cellular Localisation | NucleusCytoplasmRecycling EndosomeCytoskeletonAssociated With Recycling Endosomes And The Cytoskeletal Fraction Upon Rap2a Overexpression |
| Alternative Antibody Names | Anti-Traf2 And Nck-Interacting Protein Kinase antibodyAnti-TNIK antibodyAnti-KIAA0551 antibody |
Information sourced from Uniprot.org