| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000IHC-P:1:100-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TNFRSF11A |
| Gene ID: | 8792 |
| Uniprot ID: | TNR11_HUMAN |
| Immunogen Region: | 466-616 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 466-616 of human TNFRSF11A (NP_003830.1). |
| Immunogen Sequence: | RGPLPQCAYGMGLPPEEEAS RTEARDQPEDGADGRLPSSA RAGAGSGSSPGGQSPASGNV TGNSNSTFISSGQVMNFKGD IIVVYVSQTSQEGAAAAAEP MGRPVQEETLARRDSFAGNG PRFPDPCGGPEGLREPEKAS RPVQEQGGAKA |
| Tissue Specificity | Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. |
| Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL.essential for RANKL-mediated osteoclastogenesis. Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2. Involved in the regulation of interactions between T-cells and dendritic cells. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 11aOsteoclast Differentiation Factor ReceptorOdfrReceptor Activator Of Nf-KbCd Antigen Cd265 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftIsoform Rank-E5a: Cell Membrane |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 11a antibodyAnti-Osteoclast Differentiation Factor Receptor antibodyAnti-Odfr antibodyAnti-Receptor Activator Of Nf-Kb antibodyAnti-Cd Antigen Cd265 antibodyAnti-TNFRSF11A antibodyAnti-RANK antibody |
Information sourced from Uniprot.org