Anti-TNFRSF11A antibody (30-212 aa) [SRM5278] (STJ11107180)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal TNFRSF11A (30-212 aa) antibody for use in WB, IF, ICC and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM5278 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFRSF11A |
| Gene ID | 8792 |
| Uniprot ID | TNR11_HUMAN |
| Immunogen Region | 30-212 aa |
| Immunogen Sequence | IAPPCTSEKHYEHLGRCCNK CEPGKYMSSKCTTTSDSVCL PCGPDEYLDSWNEEDKCLLH KVCDTGKALVAVVAGNSTTP RRCACTAGYHWSQDCECCRR NTECAPGLGAQHPLQLNKDT VCKPCLAGYFSDAFSSTDKC RPWTNCTFLGKRVEHHGTEK SDAVCSSSLPARKPPNEPHV YLP |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 30-212 of human TNFRSF11A (NP_003830.1). |
Additional Info
| Tissue Specificity | Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. |
| Function | Receptor for TNFSF11/RANKL/TRANCE/OPGL.essential for RANKL-mediated osteoclastogenesis. Its interaction with EEIG1 promotes osteoclastogenesis via facilitating the transcription of NFATC1 and activation of PLCG2. Involved in the regulation of interactions between T-cells and dendritic cells. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 11aOsteoclast Differentiation Factor ReceptorOdfrReceptor Activator Of Nf-KbCd Antigen Cd265 |
| Database Links | Reactome: R-HSA-5668541Reactome: R-HSA-5676594 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinMembrane RaftIsoform Rank-E5a: Cell Membrane |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 11a antibodyAnti-Osteoclast Differentiation Factor Receptor antibodyAnti-Odfr antibodyAnti-Receptor Activator Of Nf-Kb antibodyAnti-Cd Antigen Cd265 antibodyAnti-TNFRSF11A antibodyAnti-RANK antibody |
Information sourced from Uniprot.org