Anti-TNFRSF10B antibody (260-440) (STJ25885)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TNFRSF10B (260-440) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFRSF10B |
| Gene ID | 8795 |
| Uniprot ID | TR10B_HUMAN |
| Immunogen Region | 260-440 |
| Immunogen Sequence | RSSQRPGAEDNVLNEIVSIL QPTQVPEQEMEVQEPAEPTG VNMLSPGESEHLLEPAEAER SQRRRLLVPANEGDPTETLR QCFDDFADLVPFDSWEPLMR KLGLMDNEIKVAKAEAAGHR DTLYTMLIKWVNKTGRDASV HTLLDALETLGERLAKQKIE DHLLSSGKFMYLEGNADSAM S |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 260-440 of human DR5/TRAILR2/TNFRSF10B (NP_003833.4). |
Additional Info
| Tissue Specificity | Widely expressed in adult and fetal tissues.very highly expressed in tumor cell lines such as HeLaS3, K-562, HL-60, SW480, A-549 and G-361.highly expressed in heart, peripheral blood lymphocytes, liver, pancreas, spleen, thymus, prostate, ovary, uterus, placenta, testis, esophagus, stomach and throughout the intestinal tract.not detectable in brain. |
| Post Translational Modifications | (Microbial infection) Glycosylated on Arg residue by S.typhimurium protein Ssek3. |
| Function | Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 10bDeath Receptor 5Tnf-Related Apoptosis-Inducing Ligand Receptor 2Trail Receptor 2Trail-R2Cd Antigen Cd262 |
| Database Links | Reactome: R-HSA-140534Reactome: R-HSA-202733Reactome: R-HSA-3371378Reactome: R-HSA-5213460Reactome: R-HSA-5218900Reactome: R-HSA-6803211Reactome: R-HSA-69416Reactome: R-HSA-75158 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 10b antibodyAnti-Death Receptor 5 antibodyAnti-Tnf-Related Apoptosis-Inducing Ligand Receptor 2 antibodyAnti-Trail Receptor 2 antibodyAnti-Trail-R2 antibodyAnti-Cd Antigen Cd262 antibodyAnti-TNFRSF10B antibodyAnti-DR5 antibodyAnti-KILLER antibodyAnti-TRAILR2 antibodyAnti-TRICK2 antibodyAnti-ZTNFR9 antibodyAnti-UNQ160 antibodyAnti-PRO186 antibody |
Information sourced from Uniprot.org