| Host: |
Rabbit |
| Applications: |
WB/IF/IP |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNFAIP8L2 (1-184) is suitable for use in Western Blot, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200IP 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFAIP8L2 |
| Gene ID: |
79626 |
| Uniprot ID: |
TP8L2_HUMAN |
| Immunogen Region: |
1-184 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human TNFAIP8L2 (NP_078851.2). |
| Immunogen Sequence: |
MESFSSKSLALQAEKKLLSK MAGRSVAHLFIDETSSEVLD ELYRVSKEYTHSRPQAQRVI KDLIKVAIKVAVLHRNGSFG PSELALATRFRQKLRQGAMT ALSFGEVDFTFEAAVLAGLL TECRDVLLELVEHHLTPKSH GRIRHVFDHFSDPGLLTALY GPDFTQHLGKICDGLRKLLD EGKL |
| Tissue Specificity | Expressed in T-cells, B-cells, macrophages, neurons in the brain and brainstem, and stratified squamous epithelia of the esophagus, cervix and skin. |
| Post Translational Modifications | Phosphorylated by TAK1/MAP3K7.this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. Ubiquitinated in a BTRC-depdent manner.leading to degradation mediated through the proteasome pathway. |
| Function | Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness. Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity. Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells. |
| Protein Name | Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2Tipe2Tnf Alpha-Induced Protein 8-Like Protein 2Tnfaip8-Like Protein 2Inflammation Factor Protein 20 |
| Database Links | Reactome: R-HSA-1483255 |
| Cellular Localisation | CytoplasmNucleusLysosome |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2 antibodyAnti-Tipe2 antibodyAnti-Tnf Alpha-Induced Protein 8-Like Protein 2 antibodyAnti-Tnfaip8-Like Protein 2 antibodyAnti-Inflammation Factor Protein 20 antibodyAnti-TNFAIP8L2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
