Anti-TNFAIP8L2 antibody (1-184) (STJ115653)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal TNFAIP8L2 (1-184) antibody for use in WB, IF, ICC, IP and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/IP/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200IP:0.5 Mu g-4 Mu g antibody for 25 Mu g-100 Mu g extracts of whole cellsELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TNFAIP8L2 |
| Gene ID | 79626 |
| Uniprot ID | TP8L2_HUMAN |
| Immunogen Region | 1-184 |
| Immunogen Sequence | MESFSSKSLALQAEKKLLSK MAGRSVAHLFIDETSSEVLD ELYRVSKEYTHSRPQAQRVI KDLIKVAIKVAVLHRNGSFG PSELALATRFRQKLRQGAMT ALSFGEVDFTFEAAVLAGLL TECRDVLLELVEHHLTPKSH GRIRHVFDHFSDPGLLTALY GPDFTQHLGKICDGLRKLLD EGKL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-184 of human TNFAIP8L2 (NP_078851.2). |
Additional Info
| Tissue Specificity | Expressed in T-cells, B-cells, macrophages, neurons in the brain and brainstem, and stratified squamous epithelia of the esophagus, cervix and skin. |
| Post Translational Modifications | Phosphorylated by TAK1/MAP3K7.this phosphorylation triggers association with BTRC and subsequent ubiquitination and degradation. Ubiquitinated in a BTRC-depdent manner.leading to degradation mediated through the proteasome pathway. |
| Function | Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression. Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness. Also inhibits autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex. Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity. Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells. |
| Protein Name | Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2Tipe2Tnf Alpha-Induced Protein 8-Like Protein 2Tnfaip8-Like Protein 2Inflammation Factor Protein 20 |
| Database Links | Reactome: R-HSA-1483255 |
| Cellular Localisation | CytoplasmNucleusLysosome |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Alpha-Induced Protein 8-Like Protein 2 antibodyAnti-Tipe2 antibodyAnti-Tnf Alpha-Induced Protein 8-Like Protein 2 antibodyAnti-Tnfaip8-Like Protein 2 antibodyAnti-Inflammation Factor Protein 20 antibodyAnti-TNFAIP8L2 antibody |
Information sourced from Uniprot.org