| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNFAIP6 (18-277) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFAIP6 |
| Gene ID: |
7130 |
| Uniprot ID: |
TSG6_HUMAN |
| Immunogen Region: |
18-277 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 18-277 of human TNFAIP6 (NP_009046.2). |
| Immunogen Sequence: |
WGFKDGIFHNSIWLERAAGV YHREARSGKYKLTYAEAKAV CEFEGGHLATYKQLEAARKI GFHVCAAGWMAKGRVGYPIV KPGPNCGFGKTGIIDYGIRL NRSERWDAYCYNPHAKECGG VFTDPKQIFKSPGFPNEYED NQICYWHIRLKYGQRIHLSF LDFDLEDDPGCLADYVEIYD SYDDVHGFVGRYCGDELPDD IISTGNVMTLKFLSDASVTA GGFQIKYVAMDPVSKSSQG |
| Tissue Specificity | Expressed in airway epithelium and submucosal gland (at protein level). Colocalizes with bikunin at the ciliary border. Present in bronchoalveolar lavage fluid (at protein level). Expressed in mesenchymal stem cells. Found in the synovial fluid of patients with rheumatoid arthritis. |
| Post Translational Modifications | N-glycosylated. |
| Function | Major regulator of extracellular matrix organization during tissue remodeling. Catalyzes the transfer of a heavy chain (HC) from inter-alpha-inhibitor (I-alpha-I) complex to hyaluronan. Cleaves the ester bond between the C-terminus of the HC and GalNAc residue of the chondroitin sulfate chain in I-alpha-I complex followed by transesterification of the HC to hyaluronan. In the process, potentiates the antiprotease function of I-alpha-I complex through release of free bikunin. Acts as a catalyst in the formation of hyaluronan-HC oligomers and hyaluronan-rich matrix surrounding the cumulus cell-oocyte complex, a necessary step for oocyte fertilization. Assembles hyaluronan in pericellular matrices that serve as platforms for receptor clustering and signaling. Enables binding of hyaluronan deposited on the surface of macrophages to LYVE1 on lymphatic endothelium and facilitates macrophage extravasation. Alters hyaluronan binding to functionally latent CD44 on vascular endothelium, switching CD44 into an active state that supports leukocyte rolling. Modulates the interaction of chemokines with extracellular matrix components and proteoglycans on endothelial cell surface, likely preventing chemokine gradient formation. In a negative feedback mechanism, may limit excessive neutrophil recruitment at inflammatory sites by antagonizing the association of CXCL8 with glycosaminoglycans on vascular endothelium. Has a role in osteogenesis and bone remodeling. Inhibits BMP2-dependent differentiation of mesenchymal stem cell to osteoblasts. Protects against bone erosion during inflammation by inhibiting TNFSF11/RANKL-dependent osteoclast activation. |
| Protein Name | Tumor Necrosis Factor-Inducible Gene 6 ProteinHyaluronate-Binding ProteinTnf-Stimulated Gene 6 ProteinTsg-6Tumor Necrosis Factor Alpha-Induced Protein 6Tnf Alpha-Induced Protein 6 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor-Inducible Gene 6 Protein antibodyAnti-Hyaluronate-Binding Protein antibodyAnti-Tnf-Stimulated Gene 6 Protein antibodyAnti-Tsg-6 antibodyAnti-Tumor Necrosis Factor Alpha-Induced Protein 6 antibodyAnti-Tnf Alpha-Induced Protein 6 antibodyAnti-TNFAIP6 antibodyAnti-TSG6 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
