| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TNFAIP1 (90-160) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TNFAIP1 |
| Gene ID: |
7126 |
| Uniprot ID: |
BACD2_HUMAN |
| Immunogen Region: |
90-160 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 90-160 of human TNFAIP1 (NP_066960.1). |
| Immunogen Sequence: |
DTITLPQNRQEIKELMAEAK YYLIQGLVNMCQSALQDKKD SYQPVCNIPIITSLKEEERL IESSTKPVVKL |
| Post Translational Modifications | Phosphorylation at Ser-280 by CK2 facilitates the nucleus localization and increases interaction with PCNA. |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in regulation of cytoskeleton structure. The BCR(TNFAIP1) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome, thereby regulating the actin cytoskeleton and cell migration. Its interaction with RHOB may regulate apoptosis. May enhance the PCNA-dependent DNA polymerase delta activity. |
| Protein Name | Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 2Hbacurd2Btb/Poz Domain-Containing Protein Tnfaip1Protein B12Tumor Necrosis Factor - Alpha-Induced Protein 1 - Endothelial |
| Database Links | Reactome: R-HSA-9696264Reactome: R-HSA-9696270 |
| Cellular Localisation | CytoplasmNucleusEndosomeColocalizes With Rhob In Endosomes |
| Alternative Antibody Names | Anti-Btb/Poz Domain-Containing Adapter For Cul3-Mediated Rhoa Degradation Protein 2 antibodyAnti-Hbacurd2 antibodyAnti-Btb/Poz Domain-Containing Protein Tnfaip1 antibodyAnti-Protein B12 antibodyAnti-Tumor Necrosis Factor - Alpha-Induced Protein 1 - Endothelial antibodyAnti-TNFAIP1 antibodyAnti-BACURD2 antibodyAnti-EDP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
