Anti-TNF-RI antibody [HM104] (STJ16100930)
SPECIFICATIONS
ClonalityMonoclonal
HostRat
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Rat monoclonal anti-TNF-RI for use in IHC-F, FC, ELISA and IP in Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-F/FC/ELISA/IP |
| Host | Rat |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | HM104 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 100 Mu g/mL |
| Formulation | PBS with 0.1% BSA and 0.02% sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | TNFRSF1A |
| Gene ID | 7132 |
| Uniprot ID | TNR1A_HUMAN |
Additional Info
| Post Translational Modifications | The soluble form is produced from the membrane form by proteolytic processing. (Microbial infection) Glycosylated at Arg-376 by enteropathogenic E.coli protein NleB1 and S.typhimurium protein Ssek3: arginine GlcNAcylation prevents homotypic/heterotypic death domain interactions. |
| Function | Receptor for TNFSF2/TNF-alpha and homotrimeric TNFSF1/lymphotoxin-alpha. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Contributes to the induction of non-cytocidal TNF effects including anti-viral state and activation of the acid sphingomyelinase. |
| Protein Name | Tumor Necrosis Factor Receptor Superfamily Member 1aTumor Necrosis Factor Receptor 1Tnf-R1Tumor Necrosis Factor Receptor Type ITnf-RiTnfr-IP55P60Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1Tbpi |
| Database Links | Reactome: R-HSA-5357786Reactome: R-HSA-5357905Reactome: R-HSA-5357956Reactome: R-HSA-5626978Reactome: R-HSA-5669034Reactome: R-HSA-6783783Reactome: R-HSA-75893 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinGolgi Apparatus MembraneSecretedA Secreted Form Is Produced Through Proteolytic ProcessingIsoform 4: SecretedLacks A Golgi-Retention MotifIs Not Membrane Bound And Therefore Is Secreted |
| Alternative Antibody Names | Anti-Tumor Necrosis Factor Receptor Superfamily Member 1a antibodyAnti-Tumor Necrosis Factor Receptor 1 antibodyAnti-Tnf-R1 antibodyAnti-Tumor Necrosis Factor Receptor Type I antibodyAnti-Tnf-Ri antibodyAnti-Tnfr-I antibodyAnti-P55 antibodyAnti-P60 antibodyAnti-Cd Antigen Cd120a Cleaved Into - Tumor Necrosis Factor Receptor Superfamily Member 1a - Membrane Form - Tumor Necrosis Factor-Binding Protein 1 antibodyAnti-Tbpi antibodyAnti-TNFRSF1A antibodyAnti-TNFAR antibodyAnti-TNFR1 antibody |
Information sourced from Uniprot.org