Anti-TMT1A antibody (STJA0009433)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human METTL7A
General Information
| Short Description | Rabbit polyclonal anti-N6-adenosine-methyltransferase TMT1A for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMT1A |
| Gene ID | 25840 |
| Uniprot ID | TMT1A_HUMAN |
| Immunogen | Synthesized peptide derived from human METTL7A |
| Specificity | This antibody detects endogenous levels of METTL7A at Human |
Additional Info
| Post Translational Modifications | Methylated at lysine residues most likely by EZH2. |
| Function | Thiol S-methyltransferase that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine to alkyl and phenolic thiol-containing acceptor substrates. Together with TMT1B accounts for most of S-thiol methylation activity in the endoplasmic reticulum of hepatocytes. Able to methylate the N6 position of adenosine residues in long non-coding RNAs (lncRNAs). May facilitate lncRNAs transfer into exosomes at the tumor-stroma interface. Promotes osteogenic and odontogenic differentiation by regulating the expression of genes involved in stem cell differentiation and survival. Targeted from the endoplasmic reticulum to lipid droplets, where it recruits cellular proteins to form functional organelles. (Microbial infection) May be involved in the assembly and release stages of hepatitis C virus (HCV) life cycle and thus play a crucial role in HCV propagation. |
| Protein Name | Thiol S-Methyltransferase Tmt1aMethyltransferase-Like Protein 7aN6-Adenosine-Methyltransferase Tmt1aProtein Aam-BThiol Methyltransferase 1a |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Lipid DropletEndoplasmic ReticulumMembraneMicrosomeCytoplasmCytosolInserted In The Er Membrane And Migrates From The Inserted Site To Lipid Droplet |
| Alternative Antibody Names | Anti-Thiol S-Methyltransferase Tmt1a antibodyAnti-Methyltransferase-Like Protein 7a antibodyAnti-N6-Adenosine-Methyltransferase Tmt1a antibodyAnti-Protein Aam-B antibodyAnti-Thiol Methyltransferase 1a antibodyAnti-TMT1A antibodyAnti-METTL7A antibodyAnti-PRO0066 antibodyAnti-UNQ1902 antibodyAnti-PRO4348 antibody |
Information sourced from Uniprot.org