Anti-TMPRSS6 antibody (77-220) (STJ11103816)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal Transmembrane Protease Serine 6 (77-220) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMPRSS6 |
| Gene ID | 164656 |
| Uniprot ID | TMPS6_HUMAN |
| Immunogen Region | 77-220 |
| Immunogen Sequence | GYKAEVMVSQVYSGSLRVLN RHFSQDLTRRESSAFRSETA KAQKMLKELITSTRLGTYYN SSSVYSFGEGPLTCFFWFIL QIPEHRRLMLSPEVVQALLV EELLSTVNSSAAVPYRAEYE VDPEGLVILEASVKDIAALN STLG |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 77-220 of human TMPRSS6 (NP_705837.1). |
Additional Info
| Post Translational Modifications | The single-chain zymogen undergoes autoproteolytic processing. This results in TMPRSS6 shedding from the cell surface and conversion into an activated two-chains form which is released extracellularly. The process involves a trans-activation mechanism that requires TMPRSS6 oligomerization. |
| Function | Membrane-bound serine protease. Through the cleavage of cell surface hemojuvelin (HJV), a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis. |
| Protein Name | Transmembrane Protease Serine 6Matriptase-2 |
| Database Links | Reactome: R-HSA-1442490Reactome: R-HSA-1474228 |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinThe ProcessedActivated Two-Chains Form Is Released In The Extracellular Space |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 6 antibodyAnti-Matriptase-2 antibodyAnti-TMPRSS6 antibodyAnti-UNQ354 antibodyAnti-PRO618 antibody |
Information sourced from Uniprot.org