Anti-TMPRSS4 antibody (Internal) (STJ71438)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TMPRSS4 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Approx 48kDa band observed in lysates of cell line HEK293 (calculated MW of 48.2kDa according to NP_063947.1 and of 47.6kDa according to NP_001077416.1). Recommended concentration: 0.5 |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TMPRSS4 |
| Gene ID | 56649 |
| Uniprot ID | TMPS4_HUMAN |
| Accession Number | NP_063947.1; NP_001077416.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | DSTRCNADDAYQGE |
| Specificity | This antibody is expected to recognize both reported isoforms (NP_063947.1 and NP_001077416.1). |
Additional Info
| Post Translational Modifications | Proteolytically processed.probably by an autocatalytic mechanism. |
| Function | Plasma membrane-anchored serine protease that directly induces processing of pro-uPA/PLAU into the active form through proteolytic activity. Seems to be capable of activating ENaC. (Microbial infection) In gut epithelial cells, facilitates human coronavirus SARS-CoV-2 infection through, at least, the cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry. |
| Protein Name | Transmembrane Protease Serine 4Channel-Activating Protease 2Caph2Membrane-Type Serine Protease 2Mt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTransmembrane Protease Serine 4 Catalytic Chain: SecretedActivated By Cleavage And Secreted |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 4 antibodyAnti-Channel-Activating Protease 2 antibodyAnti-Caph2 antibodyAnti-Membrane-Type Serine Protease 2 antibodyAnti-Mt-Sp2 Cleaved Into - Transmembrane Protease Serine 4 Catalytic Chain antibodyAnti-TMPRSS4 antibodyAnti-TMPRSS3 antibodyAnti-UNQ776 antibodyAnti-PRO1570 antibody |
Information sourced from Uniprot.org