Anti-TMPRSS13 antibody (STJA0004745)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenFusion protein of human TMPRSS13
General Information
| Short Description | Rabbit polyclonal anti-Transmembrane Protease Serine 13 for use in IHC and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Affinity purification |
| Dilution Range | IHC 1:30-150 |
| Formulation | PBS with 0.05% sodium azide and 50% glycerol, PH7.4 |
| Storage Instruction | Store at-20°C for the long term, and avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | TMPRSS13 |
| Gene ID | 84000 |
| Uniprot ID | TMPSD_HUMAN |
| Immunogen | Fusion protein of human TMPRSS13 |
Additional Info
| Tissue Specificity | Expressed in placenta. Isoform 1: Predominantly expressed in lung, placenta, pancreas, and prostate. Isoform 3: Expressed in lung, placenta, pancreas, and prostate. Weakly expressed in testis and peripheral blood lymphocytes. |
| Post Translational Modifications | The inactive zymogen is post-translationally modified and then trafficked to the cell surface, whereby it undergoes autocatalytic cleavage resulting in an activated form that is released extracellularly. Phosphorylation is required for localization at the cell surface. Phosphorylation increases following inhibition of protease activity by SPINT2/HAI-2. N-glycosylation of Asn-405 and Asn-445 is required for exit from the endoplasmic reticulum and trafficking to the cell surface. Also required for autocleavage of the zymogen, activation and secretion of the mature protein. |
| Function | Serine protease. Cleaves the proform of PRSS8/prostasin to form the active protein. Cleaves the proform of HGF to form the active protein which promotes MAPK signaling. Promotes the formation of the stratum corneum and subsequently the epidermal barrier in embryos. |
| Protein Name | Transmembrane Protease Serine 13Membrane-Type Mosaic Serine ProteaseMosaic Serine Protease |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinSecretedCytoplasmThe Non-PhosphorylatedInactive Full Length Protein Localizes IntracellularlyN-Glycosylation And Phosphorylation Is Required For Trafficking To The Cell SurfaceInteraction With Spint1/Hai-1 And Spint2/Hai-2 Facilitate Its Translocation To The Cell SurfaceProteolytic Cleavage Is Required For Secretion |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 13 antibodyAnti-Membrane-Type Mosaic Serine Protease antibodyAnti-Mosaic Serine Protease antibodyAnti-TMPRSS13 antibodyAnti-MSP antibodyAnti-TMPRSS11 antibody |
Information sourced from Uniprot.org