Anti-TMPRSS12 antibody (185-235 aa) (STJ196081)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human TMPSC at the amino acid range 185-235
General Information
| Short Description | Rabbit polyclonal anti-Transmembrane protease serine 12 (185-235 aa) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMPRSS12 |
| Gene ID | 283471 |
| Uniprot ID | TMPSC_HUMAN |
| Immunogen | Synthesized peptide derived from the human TMPSC at the amino acid range 185-235 |
| Immunogen Region | 185-235 aa |
| Specificity | This antibody detects endogenous levels of TMPSC at Human/Mouse |
Additional Info
| Function | Required for male fertility. Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis. Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm. Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation. |
| Protein Name | Transmembrane Protease Serine 12 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleAcrosomeExpression In The Acrosome Decreases After Acrosome Reaction |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 12 antibodyAnti-TMPRSS12 antibody |
Information sourced from Uniprot.org