| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transmembrane protease serine 12 (185-235 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMPRSS12 |
| Gene ID: |
283471 |
| Uniprot ID: |
TMPSC_HUMAN |
| Immunogen Region: |
185-235 aa |
| Specificity: |
This antibody detects endogenous levels of TMPSC at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human TMPSC at the amino acid range 185-235 |
| Function | Required for male fertility. Plays a critical role in sperm capacitation and acrosome reactions during fertilization, and also plays a role in the regulation of proteins involved in spermatogenesis. Regulates protein pathways that promote chromosomal synapsis formation, double-strand break repair, formation of the inner mitochondrial membrane cristae and apoptosis in developing sperm. Required for normal sperm motility and binding to the zona pellucida, potentially via a role in ADAM3 protein maturation. |
| Protein Name | Transmembrane Protease Serine 12 |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinCytoplasmic VesicleSecretory VesicleAcrosomeExpression In The Acrosome Decreases After Acrosome Reaction |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 12 antibodyAnti-TMPRSS12 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
