Anti-TMPRSS11D/HAT antibody (Internal) (STJ71960)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-TMPRSS11D/HAT (Internal) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:8000.WB: Preliminary experiments gave an approx 20kDa band in lysates of HepG2 after 1µg/ml antibody staining. Please note that currently we cannot find an explanation in the literature for the |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | TMPRSS11D |
| Gene ID | 9407 |
| Uniprot ID | TM11D_HUMAN |
| Accession Number | NP_004253.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | HNNYKSATHEND |
Additional Info
| Function | May play some biological role in the host defense system on the mucous membrane independently of or in cooperation with other substances in airway mucous or bronchial secretions. Plays a role in the proteolytic processing of ACE2. Proteolytically cleaves and activates the human coronavirus 229E (HCoV-229E) spike glycoprotein which facilitate virus-cell membrane fusions.spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Preferentially cleaves the C-terminal side of arginine residues at the P1 position of certain peptides, cleaving Boc-Phe-Ser-Arg-4-methylcoumaryl-7-amide most efficiently and having an optimum pH of 8.6 with this substrate. |
| Protein Name | Transmembrane Protease Serine 11dAirway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinActivated By Cleavage And SecretedTransmembrane Protease Serine 11d Catalytic Chain: Secreted |
| Alternative Antibody Names | Anti-Transmembrane Protease Serine 11d antibodyAnti-Airway Trypsin-Like Protease Cleaved Into - Transmembrane Protease Serine 11d Non-Catalytic Chain - Transmembrane Protease Serine 11d Catalytic Chain antibodyAnti-TMPRSS11D antibodyAnti-HAT antibody |
Information sourced from Uniprot.org