| Short Description : | Rabbit polyclonal TMOD1 (1-359) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:1000-1:4000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TMOD1 |
| Gene ID: | 7111 |
| Uniprot ID: | TMOD1_HUMAN |
| Immunogen Region: | 1-359 |
| Immunogen Sequence: | MSYRRELEKYRDLDEDEILG ALTEEELRTLENELDELDPD NALLPAGLRQKDQTTKAPTG PFKREELLDHLEKQAKEFKD REDLVPYTGEKRGKVWVPKQ KPLDPVLESVTLEPELEEAL ANASDAELCDIAAILGMHTL MSNQQYYQALSSSSIMNKEG LNSVIKPTQYKPVPDEEPNS TDVEETLERIKNNDPKLEEV NLNNIRNIPIPTLKAYAEAL KENSYVKKFSIVGTRSNDP |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-359 of human TMOD1 (NP_003266.1). |
| Tissue Specificity | Highly expressed in the erythrocyte, heart and skeletal muscle. |
| Function | Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton. May play an important role in regulating the organization of actin filaments by preferentially binding to a specific tropomyosin isoform at its N-terminus. |
| Protein Name | Tropomodulin-1Erythrocyte TropomodulinE-Tmod |
| Database Links | Reactome: R-HSA-390522 |
| Cellular Localisation | CytoplasmCytoskeletonIn Myofibrils With Sarcomeric StructureLocalizes To The Pointed End Of Actin Thin Filaments |
| Alternative Antibody Names | Anti-Tropomodulin-1 antibodyAnti-Erythrocyte Tropomodulin antibodyAnti-E-Tmod antibodyAnti-TMOD1 antibodyAnti-D9S57E antibodyAnti-TMOD antibody |
Information sourced from Uniprot.org
