• Western blot analysis of extracts of various cell lines, using TMEM43 antibody (STJ110807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5s.
  • Western blot analysis of extracts of various cell lines, using TMEM43 antibody (STJ110807) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 5s.

Anti-TMEM43 antibody (80-310) (STJ110807)

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STJ110807

£112.50 - £522.50
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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-TMEM43 (80-310) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TMEM43
Gene ID: 79188
Uniprot ID: TMM43_HUMAN
Immunogen Region: 80-310
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 80-310 of human TMEM43 (NP_077310.1).
Immunogen Sequence: VAPENEGRLVHIIGALRTSK LLSDPNYGVHLPAVKLRRHV EMYQWVETEESREYTEDGQV KKETRYSYNTEWRSEIINSK NFDREIGHKNPSAMAVESFM ATAPFVQIGRFFLSSGLIDK VDNFKSLSLSKLEDPHVDII RRGDFFYHSENPKYPEVGDL RVSFSYAGLSGDDPDLGPAH VVTVIARQRGDQLVPFSTKS GDTLLLLHHGDFSAEEVFHR ELRSNSMKTWG
Tissue Specificity Highest expression in placenta. Also found at lower levels in heart, ovary, spleen, small intestine, thymus, prostate and testis.
Function May have an important role in maintaining nuclear envelope structure by organizing protein complexes at the inner nuclear membrane. Required for retaining emerin at the inner nuclear membrane. Plays a role in the modulation of innate immune signaling through the cGAS-STING pathway by interacting with RNF26. In addition, functions as a critical signaling component in mediating NF-kappa-B activation by acting downstream of EGFR and upstream of CARD10. Contributes to passive conductance current in cochlear glia-like supporting cells, mediated by gap junctions and necessary for hearing and speech discrimination.
Protein Name Transmembrane Protein 43
Protein Luma
Cellular Localisation Endoplasmic Reticulum Membrane
Nucleus Inner Membrane
Multi-Pass Membrane Protein
Cell Membrane
Retained In The Inner Nuclear Membrane Through Interaction With Emd And A- And B-Lamins
The N- And C-Termini Are Oriented Towards The Nucleoplasm
The Majority Of The Hydrophilic Domain Resides In The Endoplasmic Reticulum Lumen
Alternative Antibody Names Anti-Transmembrane Protein 43 antibody
Anti-Protein Luma antibody
Anti-TMEM43 antibody
Anti-UNQ2564 antibody
Anti-PRO6244 antibody

Information sourced from Uniprot.org

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