| Host: |
Rabbit |
| Applications: |
IHC/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transmembrane protein 258 (15-65 aa) is suitable for use in Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC-P 1:50-200IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMEM258 |
| Gene ID: |
746 |
| Uniprot ID: |
TM258_HUMAN |
| Immunogen Region: |
15-65 aa |
| Specificity: |
This antibody detects endogenous levels of CK010 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human CK010 at the amino acid range 15-65 |
| Function | Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. Involved in ER homeostasis in the colonic epithelium. |
| Protein Name | Transmembrane Protein 258Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tmem258Oligosaccharyl Transferase Subunit Tmem258 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinEndoplasmic ReticulumCytoplasm |
| Alternative Antibody Names | Anti-Transmembrane Protein 258 antibodyAnti-Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit Tmem258 antibodyAnti-Oligosaccharyl Transferase Subunit Tmem258 antibodyAnti-TMEM258 antibodyAnti-C11orf10 antibodyAnti-HSPC005 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
