Anti-TMC2 antibody (STJ13102368)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from the 4th cytoplasmic loop of human transmembrane channel-like protein 2 (TMC2) conjugated to an immunogenic carrier protein was used as the immunogen.
General Information
| Short Description | Rabbit polyclonal anti-TMC2 for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | TMC2 |
| Gene ID | 117532 |
| Uniprot ID | TMC2_HUMAN |
| Immunogen | A synthetic peptide from the 4th cytoplasmic loop of human transmembrane channel-like protein 2 (TMC2) conjugated to an immunogenic carrier protein was used as the immunogen. |
| Specificity | Specific for TMC2. |
Additional Info
| Function | Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC2 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cell transduction current of the mammalian inner ear. |
| Protein Name | Transmembrane Channel-Like Protein 2Transmembrane Cochlear-Expressed Protein 2 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Stereocilia Tips Of The Cochlear Hair Cells And Plasma Membranes Of Cuticular Plates |
| Alternative Antibody Names | Anti-Transmembrane Channel-Like Protein 2 antibodyAnti-Transmembrane Cochlear-Expressed Protein 2 antibodyAnti-TMC2 antibodyAnti-C20orf145 antibodyAnti-UNQ907 antibodyAnti-PRO1928 antibody |
Information sourced from Uniprot.org