| Host: |
Rabbit |
| Applications: |
WB/IHC-P/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TMC1 |
| Gene ID: |
117531 |
| Uniprot ID: |
TMC1_HUMAN |
| Immunogen Region: |
600-700 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 600-700 of human TMC1 (NP_619636.2). |
| Immunogen Sequence: |
INILRLHTSMYFQCWAVMCC NVPEARVFKASRSNNFYLGM LLLILFLSTMPVLYMIVSLP PSFDCGPFSGKNRMFEVIGE TLEHDFPSWMAKILRQLSNP G |
| Tissue Specificity | Detected in fetal cochlea, and at low levels in placenta and testis. |
| Function | Pore-forming subunit of the mechanotransducer (MET) non-selective cation channel complex located at the tips of stereocilia of cochlear hair cells and that mediates sensory transduction in the auditory system. The MET complex is composed of two dimeric pore-forming ion-conducting transmembrane TMC (TMC1 or TMC2) subunits, and aided by several auxiliary proteins including LHFPL5, TMIE, CIB2/3 and TOMT, and the tip-link PCDH15. MET channel is activated by tension in the tip-link extending from the side wall of one stereocilium to the tip of the adjacent shorter stereocilium, where the channel is located. TMC1 MET channel is highly permeable to calcium and likely transports monovalent cations. Also involved in vestibular hair cells transduction current. |
| Protein Name | Transmembrane Channel-Like Protein 1Transmembrane Cochlear-Expressed Protein 1 |
| Database Links | Reactome: R-HSA-9662360Reactome: R-HSA-9662361 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Stereocilia Tips Of The Cochlear Hair Cells |
| Alternative Antibody Names | Anti-Transmembrane Channel-Like Protein 1 antibodyAnti-Transmembrane Cochlear-Expressed Protein 1 antibodyAnti-TMC1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
