Anti-TM4SF5 antibody (STJA0008532)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human TM4SF5
General Information
| Short Description | Rabbit polyclonal anti-Transmembrane 4 L6 family member 5 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TM4SF5 |
| Gene ID | 9032 |
| Uniprot ID | T4S5_HUMAN |
| Immunogen | Synthesized peptide derived from human TM4SF5 |
| Specificity | This antibody detects endogenous levels of TM4SF5 at Human |
Additional Info
| Function | Acts as a lysosomal membrane arginine sensor. Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently leads to RPS6KB1 and EIF4EBP1 phosphorylations. Facilitates cell cycle G1/S phase progression and the translocation of the CDK4-CCND1 complex into the nucleus. CDKN1B and RHOA/ROCK signaling activity are involved in TM4SF5-mediated acceleration of G1/S phase progression. |
| Protein Name | Transmembrane 4 L6 Family Member 5Tetraspan Transmembrane Protein L6h |
| Database Links | |
| Cellular Localisation | Lysosome MembraneMulti-Pass Membrane ProteinCell MembraneLocalization To Cell Membrane Increases During Conditions Of Arginine Depletion And Translocation To Lysosome Membrane Seen Upon Arginine Repletion |
| Alternative Antibody Names | Anti-Transmembrane 4 L6 Family Member 5 antibodyAnti-Tetraspan Transmembrane Protein L6h antibodyAnti-TM4SF5 antibody |
Information sourced from Uniprot.org